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Monday, July 27, 2020 | History

3 edition of Toxicogenomics found in the catalog.

Toxicogenomics

Toxicogenomics

  • 308 Want to read
  • 14 Currently reading

Published by Springer in Tokyo, New York .
Written in English

    Subjects:
  • Genetic toxicology.,
  • Genomics.,
  • Pharmacogenetics -- methods.,
  • Environmental Pollutants -- adverse effects.,
  • Gene Expression Regulation -- drug effects.,
  • Genomics -- methods.,
  • Toxicology -- methods.

  • Edition Notes

    Includes bibliographical references and index.

    StatementT. Inoue, W.D. Pennie (eds.).
    ContributionsInoue, T. 1944-, Pennie, W. D. 1966-
    Classifications
    LC ClassificationsRA1224.3 .T696 2003, RA1224.3 .T696 2003
    The Physical Object
    Paginationxxii, 228 p. :
    Number of Pages228
    ID Numbers
    Open LibraryOL18181389M
    ISBN 104431703446
    LC Control Number2002030523

    This book is designed to have a mix of chapters devoted to classical toxicology followed by those focused more on the emerging techniques of toxicogenomics and proteomics. In this way, the relevance of new technologies such as gene arrays to classical toxicologic problems is made evident. Toxicogenomics meshes toxicology with genomic technology (study of the entire expanse of genetic information in an organism) and may hold the promise of detecting changes in the expression of a person's genes if he or she is exposed to toxicants. As defined by the National Center for Toxicogenomics, toxicogenomics is the “collection.

      Read "Toxicogenomics" by available from Rakuten Kobo. The meteoric rate at which the human genome is being sequenced has presented to the research community a vast array of n Brand: Springer Japan. Toxicogenomics (TGX) is a scientific tool based on the acquisition, interpretation, and storage of information about gene expression and associated protein activity within particular cells or tissue (s) of an organism in response to toxic substances. From: A Comprehensive Guide to Toxicology in Preclinical Drug Development,

    The new science of toxicogenomics combines genomic, proteomic, and informatics technologies, and biological research can now foresee a time when there will be a full comprehension of the complex dynamic mechanisms of genetics, biochemistry, and physiology. *immediately available upon purchase as print book shipments may be delayed due to. Mechanistic toxicogenomics: design and analysis of microarray experiments / Kirstin Meyer, Susanne Schwenke, Johanna M. Beekman --A new approach to analysis and interpretation of toxicogenomic gene expression data and its importance in examining biological responses to low, environmentally relevant doses of toxicants / Julia A. Gosse, Thomas H.


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Toxicogenomics Download PDF EPUB FB2

Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies.5/5(1).

“The editors of this book are to be congratulated for their valuable arrangement of the expanding field of toxicogenomics, through its principles and application.” (Journal of Chemical Technology & Biotechnology, June ) "Most suitable for genomic scientists learning about this new inter-disciplinary field of toxicogenomics.".

Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, Our Stores Are Open Book Annex Membership Educators Gift Cards Toxicogenomics book & Events HelpPrice: $   This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology.

Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety.

This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. About this book Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants.

Written by leading scientists experienced in the application of toxicogenomics data, this book includes a complete introduction to toxicogenomics and the principles of risk assessment, examines the potential of the technology to improve risk assessment practices, and offers insight into promising future trends.5/5(1).

Toxicogenomic Technologies - Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment - NCBI Bookshelf All the information needed for life is encoded in an organism’s genome. In humans, approximat genes encode protein products, which carry out diverse biologic functions.

Introduction - Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment - NCBI Bookshelf Scientists, regulators, and the public all desire efficient and accurate approaches to assess the toxicologic effects of chemical. Book Description Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research.

A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis. In recent years, toxicogenomics has started to become fully integrated into drug safety assessment and into the efforts of the U.S.

Food and Drug Administration (FDA) to build more safety into drugs, noted Federico Goodsaid, Senior Staff Scientist in Genomics at the FDA’s Center for Drug Evaluation and Research.

Toxicogenomics has also increasingly become a major tool in the development of. The field of toxicogenomics investigates how the genome responds to environmental substances.

Chemicals can change the expression of genes, proteins, and metabolites in living cells. About this book Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their applications to toxicology research.

The first section following a general introduction is on genomics and toxicogenomics, and qPCR. Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research.

Toxicogenomics is a multidisciplinary field concerned with elucidating how the entire genome is involved in biological responses of organisms exposed to environmental toxicants and stressors. Full text available from Springer Nature Book Archives Millennium (). The mission of Department of Toxicogenomics is to explore, develop and to exploit the full potential of innovative cell technologies and genomics platforms, for the purpose of advancing mechanism-based in vitro assays using human cells, for predictive toxicology, as well as for developing novel biomarkers of toxic exposure and effect to be used.

About this book. Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information.

The inherent power of toxicogenomics derives from an amalgamation of multiple scientific disciplines that were originally drawn together to facilitate sequencing the three billion bases that comprise the human genome. Traditionally, the science of toxicology has been founded upon empirical codification of dose-related effects.

This timely book presents basic toxicology for molecular biologists and detailed approaches and methods of gene expression, protein, and metabolic global analyses Cited by: 1. Purchase Comparative Toxicogenomics, Volume 2 - 1st Edition. Print Book & E-Book. ISBN. Leveraging the Comparative Toxicogenomics Database to fill in knowledge gaps for environmental health: a test case for air pollution-induced cardiovascular disease.

Toxicol Sci. .Get this from a library! Toxicogenomics: principles and applications. [Hisham K Hamadeh; Cynthia A Afshari;] -- Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their.A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis.

Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline.